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SPECT/CT for Sentinel Lymph Node Detection in Patients With Melanoma—Reply

Ingo Stoffels, MD; André Scherag, MD; Joachim Klode, MD
JAMA. 2013;309(3):232-233. doi:10.1001/jama.2012.88573.
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In Reply: As pointed out in our article, there are limitations resulting from the study design. In addition to general concerns related to observational studies, Drs Dupuy and Heusse highlight the biases that may result from the temporal separation of the 2 cohorts, suggesting as an example a change in the surgical team by including an experienced surgeon during the later period. As described in the article, the same surgical technique was used in both cohorts.

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Figure. Kaplan-Meier Curves With Disease-Free Survival Over 48 Months for the 403 Patients From Table 3 in the Article2
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SLN indicates sentinel lymph node; SPECT/CT, single-photon emission computed tomography/computed tomography.



January 16, 2013
Alain Dupuy, MD, PhD; Jean-Laurent Heusse, MD
JAMA. 2013;309(3):232-233. doi:10.1001/jama.2012.88570.
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