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Letters | January 9, 2013

Strategies for Tailoring Asthma Treatment in Adults—Reply

William J. Calhoun, MD; Homer A. Boushey, MD; Bill T. Ameredes, PhD; for the Asthma Clinical Research Network BASALT Trial Investigators

JAMA. 2013;309(2):136-137. doi:10.1001/jama.2012.73385.

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In Reply: Drs Sterk and Sont authored a seminal study on asthma treatment algorithms,¹ but the purpose of BASALT was quite different from their work. Our purpose was to assess the utility of symptoms as a guide to controller therapy, compared with their purpose to assess the added value of another biomarker (ie, bronchial hyperresponsiveness) to asthma control.

Although the performance characteristics of sputum eosinophils is slightly better than that of exhaled nitric oxide, the penetrance of sputum eosinophil measurements into clinical practice in the United States and in most of the world has been negligible due to the difficulty of establishing reproducible and reliable sputum processing and cytological examination in the clinical setting. Someday sputum measures may be made reproducibly and technically simple enough to be performed routinely in the office setting, but the state of standard clinical technology is not there yet.

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January 9, 2013

Strategies for Tailoring Asthma Treatment in Adults

Gene L. Colice, MD

JAMA. 2013;309(2):136-137. doi:10.1001/jama.2012.73382.

January 9, 2013

Strategies for Tailoring Asthma Treatment in Adults—Reply

William J. Calhoun, MD; Homer A. Boushey, MD; Bill T. Ameredes, PhD; for the Asthma Clinical Research Network BASALT Trial Investigators

JAMA. 2013;309(2):136-137. doi:10.1001/jama.2012.73385.

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Calhoun WJ, Boushey HA, Ameredes BT, Asthma Clinical Research Network BASALT Trial Investigators f. Strategies for Tailoring Asthma Treatment in Adults—Reply. JAMA. 2013;309(2):136-137. doi:10.1001/jama.2012.73385.

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