We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
JAMA Patient Page |

Severe Combined Immunodeficiency FREE

Ann R. Punnoose, MD; Cassio Lynm, MA; Robert M. Golub, MD
JAMA. 2013;309(1):98. doi:10.1001/jama.2012.6226.
Text Size: A A A
Published online

The immune system is made up of the different tissues and cells in the body that fight infections. This system includes the bone marrow, in which the different kinds of white blood cells that fight infection are formed. There are several types of immunodeficiencies, or diseases in which the immune system does not work normally. Some immunodeficiencies are congenital (present at birth) while others are acquired (develop later in life; for example, as a result of infections or medications).

Severe combined immunodeficiency (SCID) results from genetic mutations (changes in genetic material that can be passed on to children) that result in very small numbers of T cells or B cells (types of cells required for a normally functioning immune system). Because mutations in any 1 of at least 13 different genes can lead to SCID, there are several genetic types of SCID. The most common form is X-linked, which means that the gene is passed from mothers to their sons.


  • In several states, infants are tested for SCID on the newborn screen, a blood test performed at birth to check for several diseases that would not otherwise be identified.

  • Children with SCID can appear healthy at birth (so SCID is not diagnosed), but as they grow older they experience persistent diarrhea, failure to grow normally, fungal skin and mouth infections, and severe pneumonia from microorganisms that do not affect people with normal immune systems.

  • Affected children may also develop severe infections such as meningitis (infection of the membranes surrounding the brain and spinal cord) and sepsis (bloodstream infections). When young infants develop these complicated infections, an immunodeficiency is likely to be the underlying cause.

  • Specialized blood tests in infants with SCID will show an absence of T cells as well as a lack of response to things that stimulate T cells and a lack of antibody titers (measures of response) to any vaccines the infant has received.


  • Protection from common infections that affect children with normal immune systems by keeping the infant away from other children

  • Intravenous immunoglobulin (IVIG) is a product derived from human blood that contains antibodies (proteins) normally made in the body to fight infections. It can temporarily protect against infections.

  • A bone marrow transplant should be done as soon as possible to prevent death from severe infections. In this procedure, a donor's healthy bone marrow containing stem cells is given to an infant or a child with SCID. These stem cells produce normally functioning T cells and B cells.


  • Children with SCID are cared for by an immunologist, a physician who specializes in diseases of the immune system.

  • After bone marrow transplantation, children with SCID require vaccinations on a specially designed schedule.



To find this and previous JAMA Patient Pages, go to the Patient Page link on JAMA 's website at www.jama.com. Many are available in English and Spanish.

Sources: Immune Deficiency Foundation; National Human Genome Research Institute; American Academy of Allergy, Asthma, and Immunology

The JAMA Patient Page is a public service of JAMA. The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis. For specific information concerning your personal medical condition, JAMA suggests that you consult your physician. This page may be photocopied noncommercially by physicians and other health care professionals to share with patients. To purchase bulk reprints, call 312/464-0776.




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Spanish Patient Page: Inmunodeficiencia combinada grave

Supplemental Content

Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
T cell immune deficiency in zap70 mutant zebrafish. Mol Cell Biol Published online Sep 6, 2016;