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Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events

Charalambos Vlachopoulos, MD; Dimitrios Richter, MD; Christodoulos Stefanadis, MD, PhD
JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116651.
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To the Editor: Omega-3 PUFA supplementation was not associated with a lower risk of any cardiovascular outcome in a study by Dr Rizos and colleagues.1 These results should be interpreted with caution due to the methodological shortcomings of the study and issues of interpretation.

First, the correction for multiple comparisons applied by the authors is not suggested by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and has rarely been used in other meta-analyses. Thus, the authors introduced an unnecessarily stringent level of significance (P < .0063 instead of P < .05), hampering interpretation of the results.

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January 2, 2013
Evan J. H. Lewis, MSc
JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116654.
January 2, 2013
Ankur Sethi, MD; Mukesh Singh, MD; Rohit Arora, MD
JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116644.
January 2, 2013
Claudio Galli, MD, PhD; J. Thomas Brenna, PhD
JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116648.
January 2, 2013
Evangelos C. Rizos, MD, PhD; Evangelia E. Ntzani, MD, PhD; Moses S. Elisaf, MD, PhD
JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116657.
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