We anticipate that most JAMA Clinical Evidence Synopsis articles will be solicited by JAMA editors, who will contact authors of recent systematic reviews from the Cochrane Collaboration or the US Preventive Services Task Force that are likely to be of interest to our readers. Authors of the selected systematic reviews will be invited to prepare a JAMA Clinical Evidence Synopsis article, according to the format described above. If the authors prefer not to prepare the shorter summary for JAMA, or are unable to prepare it in a timely fashion, other authors who may not have been involved in the preparation of the original full-length systematic review may be invited to write the JAMA Clinical Evidence Synopsis article. Thus far, all 7 authors of selected full-length systematic reviews who have been invited to prepare a JAMA Clinical Evidence Synopsis article have accepted the invitation. JAMA Clinical Evidence Synopsis manuscripts will undergo peer review, typically by both content experts and generalists.