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Letters | December 26, 2012

Markers for Prediction of Cardiovascular Disease Risk

Maryam Kavousi, MD, MSc; Maarten J. G. Leening, MD, MSc; Jacqueline C. M. Witteman, PhD

JAMA. 2012;308(24):2561-2562. doi:10.1001/jama.2012.25786.

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To the Editor: The article by Dr Yeboah and colleagues¹ compared the ability of several risk markers to improve prediction of coronary heart disease (CHD) and cardiovascular disease (CVD) among individuals at intermediate risk. The authors reported that coronary artery calcium (CAC) provided superior reclassification compared with other risk markers and recommended CAC as a tool for refining cardiovascular risk prediction in individuals at intermediate risk. While the added predictive ability of CAC in CHD risk prediction was substantial and confirmed previous findings,² we believe that supporting CAC as a candidate for CVD screening based on the results is less grounded.

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December 26, 2012

Markers for Prediction of Cardiovascular Disease Risk—Reply

Joseph Yeboah, MD, MS; Philip Greenland, MD; David M. Herrington, MD, MHS

JAMA. 2012;308(24):2561-2562. doi:10.1001/jama.2012.25796.

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Kavousi M, Leening MG, Witteman JM. Markers for Prediction of Cardiovascular Disease Risk. JAMA. 2012;308(24):2561-2562. doi:10.1001/jama.2012.25786.

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