Pancreas Organ Weight in Individuals With Disease-Associated Autoantibodies at Risk for Type 1 Diabetes

The boxes represent the mid 50% of the data, the line within box represents the group mean value adjusted for age and body mass index. The high and low whiskers represent the 95th and 5th percentiles, respectively. The filled black circles represent outliers. Using the t test, the comparison between donors without diabetes and those positive for a single autoantibody only yielded a P value of .02; and for the comparison between donors without diabetes and those with type 1 diabetes yielded a P value of less than .001. A comparison between the donors positive for a single autoantibody only and those with type 1 diabetes was not performed. Statistical significance was indicated at a Bonferroni-corrected nominal α level of .025. Of note, although age and body mass index were poorly correlated with pancreas weight and failed to meet one of the assumptions of analysis of covariance, both were included into the final model because linear models that included age or body mass index by disease status group interaction terms showed that the interaction was not statistically significant.