We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Medical News & Perspectives |

Scientists Confront Joint HIV-TB Epidemics by Taking Fight to the Front Lines

Bridget M. Kuehn, MSJ
JAMA. 2012;308(19):1959-1960. doi:10.1001/jama.2012.14752.
Text Size: A A A
Published online


The emergence of extensively drug-resistant tuberculosis (XDR-TB) in patients at a rural hospital in the KwaZulu-Natal province of South Africa gained international attention in 2005. By that point, physicians had become accustomed to encountering cases of multidrug-resistant TB (MDR-TB). When first-line antibiotics failed, they knew they could turn to more toxic and less effective second-line choices. But the outbreak in KwaZulu-Natal led to the “recognition that untreatable TB was out there,” explained William R. Bishai, MD, PhD, codirector of the Johns Hopkins Center for Tuberculosis Research in Baltimore.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

William R. Bishai, MD, PhD, is leading a new institution in South Africa where basic researchers will conduct research that addresses epidemic levels of tuberculosis and HIV coinfections in the surrounding area.

(Photo credit: Andrew Cassell/Deaf Dog Productions)
Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

The KwaZulu-Natal Research Institute for Tuberculosis and HIV, opened in October, was created by the Howard Hughes Medical Institute and the University of KwaZulu-Natal to bring basic scientists together to study drug-resistant tuberculosis and HIV coinfections.

(Photo credit: Barker Sky Imaging)



Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles

Care at the Close of Life: Evidence and Experience
Overcoming the False Dichotomy of Curative vs Palliative Care for Late-Stage HIV/AIDS: "Let Me Live the Way I Want to Live, Until I Can't"

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Evidence to Support the Update