Author Contributions: Drs Koerte and Shenton had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Koerte, Reiser, Shenton.
Acquisition of data: Koerte, Ertl-Wagner, Reiser.
Analysis and interpretation of data: Koerte, Ertl-Wagner, Zafonte, Shenton.
Drafting of the manuscript: Koerte.
Critical revision of the manuscript for important intellectual content: Koerte, Ertl-Wagner, Reiser, Zafonte, Shenton.
Statistical analysis: Koerte.
Obtained funding: Koerte, Ertl-Wagner, Reiser.
Administrative, technical, or material support: Koerte, Ertl-Wagner, Reiser, Shenton.
Study supervision: Koerte, Ertl-Wagner, Reiser, Zafonte, Shenton.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Koerte reported receiving a fellowship from the German Academic Exchange Service and Else Kröner-Fresenius Stiftung; having a grant pending with the National Institutes of Health; and receiving travel expenses and accommodations from the Society for Neuropediatrics, Germany. Dr Ertl-Wagner reported serving on advisory boards for Springer Publishing, Bracco, and Philips Radiology; serving as a consultant to Munich Medical International; receiving grants to her institution from Deutsches Zentrum fuer Neurodegenerative Erkrankungen, Friedrich-Baur Stiftung, Arbeitsgemeinschaft Botulinumtoxin, Deutsche Forschungsgemeinschaft, Omnibus Stiftung, Guerbet, Merck-Serono, and the Radiological Society of North America; receiving payment for lectures from Philips, Siemens, Deutsche Roentgengesellschaft, Alfried-Krupp-Stiftung, and Bayer-Schering; receiving payment for manuscript preparation from Siemens, Springer Publishing, and Thieme Medical Publishers; receiving royalties from Springer Publishing and Thieme Medical Publishers; receiving payment for the development of educational presentations from Springer Publishing, Bracco, and Siemens; owning stock in Siemens; and receiving travel expenses and accommodations from the European Society of Radiology, the Radiological Society of North America, and Asklepios Clinics. Dr Reiser reported receiving grants to his institution from Deutsche Forschungsgemeinschaft, Eurobioimaging, the German National Cohort, Munich Cluster of Excellence M4 Imaging, and BMBG German Centers for Lung Diseases and Cardiovascular Diseases. Dr Zafonte reported receiving grants to his institution from the National Institutes of Health and the Department of Defense; serving on a board for the International Brain Injury Association; providing expert testimony for a US attorney; receiving royalties from Demos Books for a brain injury textbook; and serving on the editorial board for Elsevier. Dr Shenton reported receiving a grant to her institution from Intrust, the National Institutes of Health, the US Department of Veteran Affairs, the US Department of Defense, the National Alliance for Medical Imaging, the National Institute of Mental Health, National Alliance for Research in Schizophrenia and Depression, Fogarty International Center, National Health and Medical Research Council, and Silvio Conte Centers for Basic Translational Mental Health Research; and receiving travel expenses and accommodations from the 9th World Congress on Brain Injury.
Funding/Support: This study was supported by the Else Kröner-Fresenius Stiftung and the Deutsche Akademischer Austauschdienst (Dr Koerte). This work was also supported in part by the Intrust Posttraumatic Stress Disorder and Traumatic Brain Injury Clinical Consortium, which is funded by Department of Defense Psychological Health/Traumatic Brain Injury Research Program grant X81XWH-07-CC-CS-DoD (Drs Zafonte and Shenton), and by grant R01 NS 078337 from the National Institute of Neurological Disorders and Stroke (Dr Shenton).
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank the following colleagues for their contributions to this research: Robert A. Stern, PhD (Center for The Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, Massachusetts), for his support in interpreting our results; David Kaufmann, MD, Stefanie Immler, MD, and Denise Steffinger, certified magnetic resonance imaging technician (Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany), for assistance with participant recruitment and data acquisition; Marc Muehlmann (Institute for Clinical Radiology, Ludwig-Maximilians-University), and Maulik Purohit, MD, MPH (Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts), for assistance in data analyses and preparation of the figures; Marek Kubicki, MD, PhD, Alexander Lin, PhD, Sylvain Bouix, PhD, Yogesh Rathi, PhD, and Ofer Pasternak, PhD (Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, Massachusetts), for guidance with the methods; Ryan Eckbo, MSc (Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital), and Ruediger Laubender, MA, MPH (Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University), for assistance in the data analyses; Florian Heinen, MD (Department of Pediatric Neurology and Developmental Medicine, Ludwig-Maximilians-University), and Erin D. Bigler, PhD (Department of Psychology, Brigham Young University, Provo, Utah), for assistance in interpreting our results. None of the individuals acknowledged were compensated for their contributions.