Author Contributions: Dr Safford had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Safford, Muntner, Durant, Lewis, Cushman, V. Howard.
Acquisition of data: Safford, Prineas, Samdarshi, Lewis, V. Howard, G. Howard.
Analysis and interpretation of data: Safford, Brown, Muntner, Durant, Glasser, Halanych, Shikany, Bittner, Gamboa, Cushman, G. Howard.
Drafting of the manuscript: Safford, Gamboa.
Critical revision of the manuscript for important intellectual content: Safford, Brown, Muntner, Durant, Glasser, Halanych, Shikany, Prineas, Samdarshi, Bittner, Lewis, Cushman, V. Howard, G. Howard.
Statistical analysis: Muntner, Samdarshi, Gamboa.
Obtained funding: Safford, Prineas, G. Howard.
Administrative, technical, or material support: Safford, Brown, Durant, Lewis, Cushman, V. Howard, G. Howard.
Study supervision: Safford, Muntner, Glasser, Halanych, Cushman, V. Howard.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Brown reported receiving grants from Amgen Pharmaceuticals not related to this article. Dr Muntner reported serving on an Amgen advisory board in 2011; serving as a consultant to Amgen; and receiving grants from Amgen. Dr Lewis reported receiving a grant from NovoNordisk for an obesity study. No other authors reported any disclosures.
Funding/Support: This research project was supported by grant R01 HL080477 from the National Heart, Lung, and Blood Institute (Dr Safford); grant KL2 RR025776-04 from the National Center for Research Resources (Dr Brown); and cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services (Dr G Howard). Additional funding was provided by an investigator-initiated grant-in-aid from Amgen Corporation (Dr Safford).
Role of the Sponsors: Representatives of the funding agencies have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data. Amgen did not have any role in the design and conduct of the study; in the collection, management, data analysis, and interpretation of the data; or in the preparation or approval of the manuscript.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.