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Physical Activity to Combat Depression in Chronic Heart Failure—Reply

James A. Blumenthal, PhD; Michael A. Babyak, PhD; David J. Whellan, MD
JAMA. 2012;308(17):1738-1739. doi:10.1001/jama.2012.14098.
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In Reply: Dr Sossai and Mr Sponga suggest that we consider race and heart failure severity as potential moderators of treatment in the HF-ACTION trial1 and that we examine more thoroughly the relationship between exercise adherence and depressive symptoms measured by the BDI-II.

Because blacks may respond differently to various cardiac medications, Sossai and Sponga suggest that we examine the response of blacks to the exercise intervention. This suggestion is especially relevant because depression may be less likely to be recognized in blacks,2 and is even less likely to be treated.3 However, the absence of a treatment group × race interaction for BDI-II scores in the HF-ACTION trial suggests that blacks responded to exercise in a similar manner compared with their white counterparts. We plan to examine this issue in greater detail in a subsequent report.


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November 7, 2012
Paolo Sossai, MD; Baldovino Sponga, BSc
JAMA. 2012;308(17):1738-1739. doi:10.1001/jama.2012.14095.
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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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