Author Contributions: Dr Joosten had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Joosten, Pai, Mukamal.
Acquisition of data: Pai, Rimm, Mukamal.
Analysis and interpretation of data: Joosten, Pai, Bertoia, Rimm, Spiegelman, Mittleman, Mukamal.
Drafting of the manuscript: Joosten.
Critical revision of the manuscript for important intellectual content: Joosten, Pai, Bertoia, Rimm, Spiegelman, Mittleman, Mukamal.
Statistical analysis: Joosten, Bertoia, Spiegelman, Mittleman.
Obtained funding: Pai, Mukamal.
Administrative, technical, or material support: Joosten, Pai.
Study supervision: Rimm, Mukamal.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Mittleman reported institutional grant support from the National Heart, Lung, and Blood Institute; and receiving or having institutional grants pending from the National Institutes of Health, the Environmental Protection Agency, and Health Effects Institute. Dr Mukamal reported institutional grant support from the National Heart, Lung, and Blood Institute and the National Institutes of Health; and institutional support in the form of active and placebo capsules provided from the Martek Corporation to Harvard Medical School for a trial of docosahexaenoic acid for periodontitis. No other author reported disclosures.
Funding/Support: This work was supported by National Institutes of Health grants R01 HL091874, HL35464, and CA55075.
Role of the Sponsor: The National Institutes of Health had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Additional Contributions: We thank Lydia Liu, MSc (Department of Nutrition of the Harvard School of Public Health), for statistical and programming assistance; Ms Liu did not recieve additional compensation for her contribution above her normal salary from Harvard.