The results of the National Lung Screening Trial (NLST) have led to renewed interest in lung cancer screening. The NLST demonstrated that lung cancer screening using computed tomography (CT) reduces lung cancer–specific mortality by more than 20% and overall mortality by 7%.1 Although the discussion about false-positive findings is unsettling and cost-effectiveness analysis and confirmation by other large randomized trials are still being awaited, guidelines have been released by major organizations in the United States recommending lung cancer screening for patients who meet the inclusion criteria of the NLST.2
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