Author Contributions: Dr Melander had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Melander, Bergmann, Orho-Melander.
Acquisition of data: Melander, Manjer, Hedblad, Bergmann, Orho-Melander.
Analysis and interpretation of data: Melander, Maisel, Almgren, Manjer, Belting, Hedblad, Engström, Kilger, Nilsson, Orho-Melander.
Drafting of the manuscript: Melander, Maisel, Bergmann.
Critical revision of the manuscript for important intellectual content: Melander, Maisel, Almgren, Manjer, Belting, Hedblad, Engström, Kilger, Nilsson, Bergmann, Orho-Melander.
Statistical analysis: Melander, Maisel, Almgren, Engström, Orho-Melander.
Obtained funding: Melander, Hedblad, Bergmann, Orho-Melander.
Administrative, technical, or material support: Melander, Maisel, Manjer, Hedblad, Bergmann, Orho-Melander.
Study supervision: Melander, Belting, Engström, Kilger, Bergmann.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Bergmann reports being the president of Sphingo Tec GmbH, which holds the patent rights for use of proneurotensin in prediction of diabetes, cardiovascular disease, and breast cancer; and also holding stock/stock options with SphingoTec GmbH. Dr Melander reports being listed as inventor on the same patent application. Dr Maisel reports provision of consultancy services for SphingoTec GmbH. Dr Engström reports being employed as a senior epidemiologist by AstraZeneca R&D. The other authors reported no disclosures.
Funding/Support: Funding was obtained from the European Research Council (StG-282255) (Dr Melander); the Swedish Heart and Lung Foundation, and the Swedish Research Council (Drs Melander and Orho-Melander); the Skåne University Hospital donation funds; the Medical Faculty, Lund University (Dr Melander); the governmental funding of clinical research within the national health services (Drs Melander and Orho-Melander); and the Albert Påhlsson Research Foundation, Region Skane, the King Gustaf V and Queen Victoria Foundation, and the Marianne and Marcus Wallenberg Foundation (Dr Melander).
Role of the Sponsors: The funding organizations had no role in the design and conduct of the study; the collection, management, analyses, and interpretation of the data; or the preparation or approval of the manuscript.