Author Contributions: Dr Bangalore had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bangalore, Steg, Deedwania, Eagle, Ohman, Cannon, Bhatt.
Acquisition of data: Steg, Crowley, Goto, Zeymer, Bhatt.
Analysis and interpretation of data: Bangalore, Steg, Deedwania, Crowley, Eagle, Cannon, Smith, Zeymer, Hoffman, Messerli, Bhatt.
Drafting of the manuscript: Bangalore, Crowley, Messerli.
Critical revision of the manuscript for important intellectual content: Bangalore, Steg, Deedwania, Crowley, Eagle, Goto, Ohman, Cannon, Smith, Zeymer, Hoffman, Messerli, Bhatt.
Statistical analysis: Crowley, Hoffman.
Obtained funding: Steg, Goto, Cannon.
Administrative, technical, or material support: Steg, Eagle, Ohman, Cannon.
Study supervision: Bangalore, Steg, Deedwania, Goto, Messerli, Bhatt.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Steg reported receiving a research grant from sanofi-aventis and Servier awarded to INSERM U-698 and the New York University School of Medicine; serving as a consultant or receiving speakers fees from Ablynx, Amarin, Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Meyers Squibb, Daiichi Sankyo, Eisai, GlaxoSmithKline, Lilly, Medtronic, Merck Sharp & Dohme, Novartis, Otsuka, Pfizer, Roche, sanofi-aventis, Servier, the Medicines Company; and holding stock in Aterovax. Dr Deedwania reported serving as a consultant or receiving speakers fees from Forest Pharmaceuticals, Novartis, Daichii Sankyo, Servier, and Pfizer. Dr Goto reported receiving consulting fees and honoraria from Eisai, sanofi-aventis, Otsuka, Bayer, Novartis, AstraZeneca, Asteras, Pfizer, Medtronics Japan, Mitsubishi Tanabe, Takeda, Daiichi Sankyo, Mochida, Merck Sharp & Dohme; and receiving research grants from sanofi-aventis, Eisai, Boehringer Ingelheim, Otsuka, and Daiichi Sankyo. Dr Ohman reported receiving research grants from Daiichi Sankyo, Eli Lilly & Company, Maquet; serving as a consultant to AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, LipoScience, Merck, Pozen, Roche, sanofi-aventis, the Medicines Company, and WebMD; and serving on the speakers bureau for Boehringer Ingelheim, Gilead Sciences, and the Medicines Company. Dr Cannon reported receiving research grants or support from Accumetrics, AstraZeneca, Essentials, GlaxoSmithKline, Merck, Regeneron, sanofi-aventis, and Takeda; serving on advisory boards (but funds donated to charity) for Bristol-Myers Squibb, Alnylam, Pfizer, and CSL; receiving honoraria for the development of independent educational symposia for Pfizer and AstraZeneca; and serving as a clinical advisor for and owning equity in Automedics Medical Systems. Dr Bhatt reported serving on an advisory board for Medscape Cardiology; serving on the boards of directors for Boston VA Research Institute and the Society of Chest Pain Centers; serving as chair for the American Heart Association Get With The Guidelines Science Subcommittee; receiving honoraria from the American College of Cardiology for serving as editor of Clinical Trials, Cardiosource, Duke Clinical Research Institute for serving on clinical trial steering committees, Slack Publications for serving as chief medical editor of Cardiology Today Intervention, and WebMD for serving on continuing medical education steering committees; serving as senior associate editor for the Journal of Invasive Cardiology ; receiving research grants from Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Medtronic, sanofi-aventis, and the Medicines Company; and unfunded research from FlowCo, PLx Pharma, and Takeda. Drs Bangalore, Eagle, Smith Jr, Zeymer, Hoffman, and Messerli and Mr Crowley did not report any disclosures.
Funding Source: The REACH Registry is sponsored by sanofi-aventis, Bristol-Myers Squibb, and the Waksman Foundation (Tokyo, Japan) and is endorsed by the World Heart Federation. Statistical analyses of the REACH database by TIMI Study Group statisticians were funded by sanofi-aventis.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Sabina Murphy, MPH, of the TIMI study group for statistical support and supervision.