Lichen nitidus on the penis can be confusing to physicians and is often treated as a cutaneous viral infection, such as condyloma acuminatum. Many penile lesions also mimic lichen nitidus and should thus be differentiated; these include pearly penile papules, molluscum contagiosum, herpetic infection, nodular scabies, and bowenoid papulosis. Pearly penile papules mainly affect the coronal sulcus with a ring-like distribution without spreading to the nearby glans penis, penile shaft, prepuce, scrotum, and trunk. Molluscum contagiosum produces papules with characteristic central umbilication. Warts or condyloma typically present with a verrucous surface or cauliflower-like appearance. Herpetic lesions usually demonstrate grouped vesicles arising from an erythematous base, and, in addition to tiny vesicles, some of the lesions may be crusted or erosive. Scabies lesions are highly pruritic red or brown papules. Bowenoid papulosis usually presents as small red, brown, or flesh-colored flat or warty lesions most commonly on the shaft of the penis, which are different from those of lichen nitidus in color and morphology.