Although rates have declined in recent years, motor vehicle crashes (MVCs) remain a leading cause of injury death in the United States.1 In 2009, a total of 34,485 MVC deaths were reported among U.S. residents, and 22% of those who died were aged 15–24 years. MVCs were the leading cause of death for that age group, which represents approximately 14% of the total U.S. population.1 To assess patterns in MVC death rates for persons of all ages and for those aged 15–24 years, in recognition of the elevated risk for this age group, CDC used data from the National Vital Statistics System (NVSS) and the U.S. Census Bureau for 2009 representing the 50 most populous U.S. metropolitan statistical areas (MSAs). The overall MVC death rate (age-adjusted) for all 50 MSAs combined was 8.2 per 100,000 residents, compared with a national rate of 11.1; among MSAs, rates ranged from 4.4 to 17.8. For persons aged 15–24 years, the MVC death rate was 13.0 per 100,000 residents for all MSAs combined (range: 7.3–25.8), compared with a national rate of 17.3. Although rates for the MSAs generally were lower than the rate for the nation as a whole, higher rates for persons aged 15–24 years were observed both in the MSAs and nationally. The wide variation in rates among MSAs suggests a need to better understand how urban development patterns might relate to MVC deaths and to identify and implement effective strategies to reduce the number of such deaths.