Author Contributions: Dr de Lemos had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Neeland, Vega, Farzaneh-Far, McGuire, de Lemos.
Acquisition of data: Neeland, Vega, McGuire, de Lemos.
Analysis and interpretation of data: Neeland, Turer, Ayers, Powell-Wiley, Vega, Farzaneh-Far, Grundy, Khera, McGuire, de Lemos.
Drafting of the manuscript: Neeland, de Lemos.
Critical revision of the manuscript for important intellectual content: Neeland, Turer, Ayers, Powell-Wiley, Vega, Farzaneh-Far, Grundy, Khera, McGuire, de Lemos.
Statistical analysis: Neeland, Ayers, Farzaneh-Far.
Obtained funding: Grundy, McGuire, de Lemos.
Administrative, technical, or material support: Neeland, Grundy, Khera, de Lemos.
Study supervision: Khera, McGuire, de Lemos.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr McGuire reported having received consulting income from F. Hoffmann LaRoche, Genentech, sanofi-aventis, Daiichi Sankyo, Novo Nordisk, and Tethys Bioscience. Dr de Lemos reported having received grant support from Roche Diagnostics, Abbott Diagnostics, and Alere; consulting income from Tethys Bioscience, AstraZeneca, and Daiichi Sankyo; and lecture honoraria from Bristol-Myers Squibb/sanofi-aventis. No other disclosures were reported.
Funding/Support: Grant support for the Dallas Heart Study was provided by the Donald W. Reynolds Foundation and by US Public Health Service General Clinical Research Center grant M01-RR00633, with additional support for the present study provided by grants UL1DE019584 and PL1DK081182 from the National Institutes of Health (NIH). Dr Neeland is supported by award T32HL007360 from the National Heart, Lung, and Blood Institute (NHLBI). Dr Powell-Wiley is funded by the Division of Intramural Research of the NHLBI of the NIH. Biomarker measurements were supported by investigator-initiated grants from Alere and Roche Diagnostics.
Role of the Sponsor: Alere, Roche Diagnostics, and the NIH had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.