In this issue of THE JOURNAL, Black and colleagues1 report
the results of an aborted clinical trial. In the Controlled Onset Verapamil
Investigation of Cardiovascular End Points (CONVINCE) study, a large randomized
double-blind equivalence trial with many strengths, the investigators compared
a controlled-onset extended-release formulation of the calcium channel blocker
verapamil with standard therapies (atenolol or hydrochlorothiazide) for hypertension.
Randomization was stratified on type of standard care—diuretics or β-blockers—with
the result that there were, in effect, 2 parallel trials within CONVINCE,
verapamil vs each of the other 2. When the rates of withdrawal from treatment
were noted to be higher than expected, the sample size was increased from
15 000 to 16 600 with a new target of 2246 primary events, which
included first myocardial infarction, stroke, or cardiovascular disease–related
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 49
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.