The US Food and Drug Administration (FDA) has warned physicians of 3 deaths and 1 severe case of respiratory depression in children who received codeine for pain relief following tonsillectomy or adenoidectomy.
The surgeries were performed to treat obstructive sleep apnea. FDA officials said it appeared that the 3 children who died, who were aged 2 to 5 years, were “ultrarapid metabolizers” who metabolize codeine much more quickly and completely than others. This trait results from a gene variant that makes the drug-metabolizing enzyme cytochrome P450 2D6 in the liver more active (http://www.fda.gov/Drugs/DrugSafety/ucm313631.htm). Overall prevalence of the inherited trait is 1% to 7% but reaches 29% in Ethiopian populations, the FDA reported. The agency has approved genetic tests that can detect the trait.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.