Author Contributions: Dr Arai had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Aletras, Dyke, Thorgeirsson, Gudnason, Harris, Arai.
Acquisition of data: Cao, Sigurdsson, Kellman, Aletras, Dyke, Gudnason, Harris.
Analysis and interpretation of data: Schelbert, Cao, Aspelund, Dyke, Thorgeirsson, Launer, Arai.
Drafting of the manuscript: Schelbert, Aspelund, Aletras, Dyke, Arai.
Critical revision of the manuscript for important intellectual content: Cao, Sigurdsson, Aspelund, Kellman, Aletras, Dyke, Thorgeirsson, Eiriksdottir, Launer, Gudnason, Harris, Arai.
Statistical analysis: Schelbert, Aspelund, Aletras, Dyke.
Obtained funding: Eiriksdottir, Launer, Gudnason, Harris, Arai.
Administrative, technical, or material support: Cao, Sigurdsson, Aletras, Thorgeirsson, Eiriksdottir, Harris, Arai.
Study supervision: Cao, Dyke, Gudnason, Arai.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was funded by the National Heart, Lung, and Blood Institute Intramural Research Program (Z01 HL004607-08 CE), the National Institute on Aging Intramural Research Program (N01-AG-12100), Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The study was approved by the Icelandic National Bioethics Committee (VSN: 00-063) and the Medstar Research Institute (project 2003-145). Dr Schelbert is supported by a T. Franklin Williams Scholarship Award, funding for which is provided by Atlantic Philanthropies, the John A. Hartford Foundation, the Association of Specialty Professors, and the American Heart Association. Dr Cao is supported by an American Heart Association Grant-in-Aid (10GRNT4580000).
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.