Author Contributions: Drs Vasan and Mitchell had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Vasan and Mitchell contributed equally to the work.
Study concept and design: Kaess, Vita, Benjamin, Vasan, Mitchell.
Acquisition of data: Benjamin, Vasan, Mitchell.
Analysis and interpretation of data: Kaess, Rong, Larson, Hamburg, Vita, Levy, Benjamin, Vasan, Mitchell.
Drafting of the manuscript: Kaess, Vasan, Mitchell.
Critical revision of the manuscript for important intellectual content: Kaess, Rong, Larson, Hamburg, Vita, Levy, Benjamin, Vasan, Mitchell.
Statistical analysis: Kaess, Rong, Larson, Mitchell.
Obtained funding: Benjamin, Vasan, Mitchell.
Administrative, technical, or material support: Levy, Vasan, Mitchell.
Study supervision: Benjamin, Vasan, Mitchell.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Mitchell reported being the owner of Cardiovascular Engineering Inc (a company that develops and manufactures devices to measure vascular stiffness) and serving as a consultant to Novartis and Merck. No other author reported ownership rights or other financial relationship with Cardiovascular Engineering Inc or any other conflicts of interest.
Funding/Support: This work was supported through contracts NO1-HC25195, HL076784, AG028321, HL070100, HL060040, HL080124, HL071039, HL077447, and HL107385 with the National Institutes of Health, National Heart, Lung, and Blood Institute, and a grant from the Donald W. Reynolds Foundation.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Online-Only Material: The Author Video Interview is