Author Contributions: Dr Canto had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Canto.
Acquisition of data: Canto.
Analysis and interpretation of data: Canto, Rogers, Peterson, Wenger, Vaccarino, Kiefe, Frederick, Sopko, Zheng.
Drafting of the manuscript: Canto.
Critical revision of the manuscript for important intellectual content: Canto, Rogers, Goldberg, Peterson, Wenger, Vaccarino, Kiefe, Frederick, Sopko, Zheng.
Statistical analysis: Canto, Peterson, Frederick.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kiefe reports receiving partial funding from the National Institutes of Health (grants U01HL 105268 and U54 RR 026088). Mr Frederick reports being an employee of ICON Clinical Research, which received support from Genentech, to provide biostatistical and analytic services. Dr Peterson reported receiving research grants from Bristol-Myers Squibb, sanofi-aventis, Eli Lilly, Schering Plough/Merck, Johnson & Johnson, and St Jude Inc and consultant fees from Bayer and Pfizer. Dr Wenger reported receiving research grants and/or trial committee or data and safety monitoring board compensation from Pfizer, Merck, NHLBT, Gilead Sciences, Abbott, and Eli Lilly; she also reported receiving consultant fees from Gilead Sciences, AstraZeneca, Abbott Women’s Advisory Board, Merck, and Pfizer.
Funding/Support: The National Registry of Myocardial Infarction was supported by Genentech.
Role of the Sponsors: The study sponsor approved the final manuscript but did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the opinions of the funding organizations. Dr Peterson, a contributing editor for JAMA, was not involved in the editorial review of or decision to publish this article.
Online-Only Material: The Author Video Interview is available here.