Published Online: August 26, 2012. doi:10.1001/2012.jama.11274
Author Contributions: Drs Min and Pencina had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Min, Leipsic, Koo, Jaffer, Shaw, Mauri.
Acquisition of data: Leipsic, Koo, van Mieghem, Erglis, Budoff, Cole, Leon, Mancini, Park, Schwartz, Mauri.
Analysis and interpretation of data: Leipsic, Pencina, Berman, Koo, van Mieghem, Lin, Dunning, Apruzzese, Leon, Malpeso, Mancini, Schwartz, Shaw, Mauri.
Drafting of the manuscript: Min, Leipsic, Koo, Erglis, Lin, Apruzzese, Leon, Schwartz, Shaw, Mauri.
Critical revision of the manuscript for important intellectual content: Leipsic, Pencina, Berman, van Mieghem, Lin, Dunning, Budoff, Cole, Jaffer, Leon, Malpeso, Mancini, Park, Schwartz, Shaw, Mauri.
Statistical analysis: Pencina, Berman, Koo, Lin, Dunning, Apruzzese, Shaw, Mauri.
Obtained funding: Mauri.
Administrative, technical, or material support: van Mieghem, Budoff, Cole, Malpeso, Mancini, Park.
Study supervision: Min, Leipsic, van Mieghem, Erglis, Budoff, Jaffer, Mancini, Schwartz, Shaw, Mauri.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Min reports research support from GE Healthcare and Philips Medical. Dr Leipsic reports research support from GE Healthcare and serving as a consultant to Edwards Lifesciences. Dr Pencina reports consulting fees from HeartFlow to his institution. Dr Berman reports research support from Siemens Medical Systems and Lantheus Medical Imaging and stock options in Spectrum Dynamics. Dr Budoff reports research support from GE Healthcare and grants to his institution from Roche and Pfizer. Dr Cole reports grant for research support from HeartFlow. Dr Jaffer reports serving as consultant to Boston Scientific, Siemens, and Merck and receiving nonfinancial research support from Abbott Vascular. Dr Mancini reports a grant to his institution from HeartFlow. Dr Mauri reports serving as a consultant to Medtronic and Cordis and receiving research support from Medtronic, Cordis, Abbott, Boston Scientific, Eli Lilly, Daiichi Sankyo, Bristol-Myers Squibb, and sanofi-aventis; she also reports grants and consulting fees paid to her institution from HeartFlow. No other disclosures were reported.
Funding/Support: This study was funded by HeartFlow Inc.
Role of the Sponsor: HeartFlow Inc had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.