The increasing availability of electronic health data combined with federal investment has stimulated an expansion in observational clinical research.1 Observational studies can complement clinical trials and provide important information about comparative safety and effectiveness in populations not well studied in clinical trials. However, there are numerous examples in which the findings from observational studies have failed to be replicated.2 These failures may be due to several factors, including the exploratory nature of observational questions, failure to fully account for treatment selection bias, known publication biases, and the tendency to pursue post hoc hypotheses. This later problem, termed data dredging, is facilitated by the lack of fidelity to a prespecified hypothesis and inadequate reporting of the actual analytic process.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 16
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.