In the 1960s, the Framingham Heart Study (FHS) investigators coined the term “factors of risk” for cardiovascular disease1; today risk factors are used routinely in daily practice to assist in risk prediction and to target prevention strategies for cardiovascular disease as well as for other diseases. The FHS investigators subsequently used risk factors to develop a multivariable model to predict the likelihood of a future coronary heart disease event. The model included several major cardiovascular risk factors that estimate the probability of developing an initial coronary disease event over the next 10 years and result in a risk score.2 This basic model is used around the globe.
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The Rational Clinical Examination
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