Author Contributions: Dr Preiss had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Preiss, Tikkanen, McMurray.
Acquisition of data: Preiss, Tikkanen, Ford, Lovato, Elam, LaRosa, Demicco, Colhoun, Goldenberg, Pedersen, Keech, Ridker, Kjekshus, McMurray.
Analysis and interpretation of data: Preiss, Tikkanen, Welsh, LaRosa, Demicco, Colhoun, Goldenberg, Murphy, MacDonald, Keech, Ridker, Sattar, McMurray.
Drafting of the manuscript: Preiss, Elam, LaRosa, Sattar, McMurray.
Critical revision of the manuscript for important intellectual content: Preiss, Tikkanen, Welsh, Ford, Lovato, Elam, LaRosa, Demicco, Colhoun, Goldenberg, Murphy, MacDonald, Pedersen, Keech, Ridker, Kjekshus, McMurray.
Statistical analysis: Preiss.
Obtained funding: Pedersen.
Administrative, technical, or material support: Welsh, Ford, Demicco, Goldenberg, Keech, Ridker.
Study supervision: Ford, LaRosa, Pedersen, Sattar, McMurray.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. The majority of trials discussed in this article were funded partly or wholly by industry, and Drs Tikkanen, Ford, Elam, LaRosa, DeMicco, Colhoun, Goldenberg, Pedersen, Keech, Ridker, Kjekshus, and McMurray and Ms Lovato each reported serving as an investigator in at least 1 of the trials. Dr Tikkanen reported receiving honoraria from Pfizer and consultant fees from Amgen Inc. Dr Elam reporting serving as a consultant, speaker, or both for Abbott/Solvay, Merck Schering Plough, and Pfizer Canada. Dr LaRosa reported receiving consultancy fees from Pfizer and AstraZeneca and participating in clinical trials funded by Pfizer. Dr Colhoun reported receiving honoraria for advisory board participation and speaker fees from Pfizer. Dr Pedersen reported receiving speakers honoraria, consulting fees, or research grants from Merck, AstraZeneca, AMGEN, Roche, and Novartis. Dr Keech reported receiving honoraria and research or travel grants from Abbott, Merck Sharpe & Dohme, Bristol-Myers Squibb, Novartis, Eli Lilly, Pfizer, Roche Diagnostics, Solvay, and AstraZeneca. Dr Ridker reported receiving research grant support from AstraZeneca and Novartis; receiving consultancy fees from Merck, Genzyme, Vascular Biogenics, ISIS, and Boston Diagnostics; and being listed as a co-inventor on patents held by the Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease and diabetes that have been licensed to AstraZeneca and Siemens. Dr Sattar reported consulting for and receiving lecture fees from Merck, Pfizer, and AstraZeneca and receiving research grant support from Pfizer. No other authors reported disclosures.
Funding/Support: This project was not supported by external funding. Dr Welsh is supported by British Heart Foundation fellowship grant FS/10/005/28147.
Role of the Sponsor: The British Heart Foundation had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We are grateful to the investigators from the following trials for providing unpublished data: Helsinki Heart Study, Bezafibrate Infarction Prevention Study, Action to Control Cardiovascular Risk in Diabetes Lipid Study, Scandinavian Simvastatin Survival Study, West of Scotland Coronary Prevention Study, Air Force/Texas Coronary Atherosclerosis Prevention Study, Long-term Intervention With Pravastatin in Ischaemic Disease Study, Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza cardiaca (GISSI) Prevenzione, Prospective Study of Pravastatin in the Elderly at Risk, Greek Atorvastatin and Coronary Heart Disease Evaluation Study, Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm, Collaborative Atorvastatin Diabetes Study, Pravastatin or Atorvastatin Evaluation and Infection Therapy Study, Aggrastat to Zocor Study, Treating to New Targets Study, Incremental Decrease in Events Through Aggressive Lipid Lowering Study, Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non–Insulin-Dependent Diabetes Mellitus, Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese Study Group, Controlled Rosuvastatin Multinational Trial in Heart Failure, Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin, and GISSI-Heart Failure. Bristol-Myers Squibb provided data for the Cholesterol and Recurrent Events Trial.