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Letters |

Probiotics for Antibiotic-Associated Diarrhea—Reply

Susanne Hempel, PhD; Jeremy N. V. Miles, PhD; Paul G. Shekelle, MD, PhD
JAMA. 2012;308(7):665-666. doi:10.1001/jama.2012.8738.
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In Reply: The objective of our review was to broadly evaluate the available evidence on probiotic interventions for the prevention or treatment of AAD. We presented sensitivity analyses, including results for studies explicitly aiming to prevent or treat AAD, which excluded wider applications, and results were virtually identical (relative risk, 0.58 [95% CI, 0.50-0.68] vs relative risk, 0.58 [95% CI, 0.49-0.68]).

Intention-to-treat analyses provide a conservative estimate of treatment effects. Studies were included in the meta-analysis if the number of participants randomized to each treatment group and the number of participants with diarrhea in each group were reported, independent of the analytic approach applied in individual studies.

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August 15, 2012
Elizabeth J. Videlock, MD; Filippo Cremonini, MD, MSc, PhD
JAMA. 2012;308(7):665-666. doi:10.1001/jama.2012.8735.
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