How best to treat posttraumatic stress disorder (PTSD) is a long-standing question. Treatments for PTSD, which began in the late 19th century, have varied greatly.1 In the current era, numerous PTSD treatments are available, some with a strong evidence base.2 In this issue of JAMA, the findings of 2 randomized controlled trials of interventions for PTSD expand the boundaries of treatment to relatively underserved populations: the trial by Mills et al3 assesses interventions in persons with PTSD and substance dependence, and the trial by Monson et al4 assesses interventions in couples in which 1 partner has PTSD.4
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