Author Contributions: Drs Grover and Kastrinos had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Grover and Kastrinos, as first authors, contributed equally to the manuscript.
Study concept and design: Grover, Syngal.
Acquisition of data: Burbidge, Wenstrup.
Analysis and interpretation of data: Grover, Kastrinos, Steyerberg, Cook, Dewanwala, Syngal.
Drafting of the manuscript: Grover, Syngal.
Critical revision of the manuscript for important intellectual content: Grover, Kastrinos, Steyerberg, Cook, Dewanwala, Burbidge, Wenstrup, Syngal.
Statistical analysis: Grover, Kastrinos, Steyerberg, Cook, Syngal.
Obtained funding: Grover, Kastrinos, Syngal.
Administrative, technical, or material support: Dewanwala, Burbidge, Wenstrup.
Study supervision: Grover, Kastrinos, Syngal.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Grover reported employment with UpToDate Inc. Dr Kastrinos reported serving as a consultant for Marinabio Inc. Dr Steyerberg reported receiving a grant from the National Institutes of Health and receiving royalties from Springer for a book on clinical prediction models. Ms Burbidge and Dr Wenstrup reported holding stock options in Myriad Genetic Laboratories Inc. Dr Syngal reported serving as a consultant for Archimedes Inc, Quest Diagnostics Inc, Interquest Inc, and Cequent Inc; holding stock options from Marinabio Inc; and receiving travel/accommodations/meeting expenses unrelated to activities listed from Myriad Genetic Laboratories Inc. No other authors reported disclosures.
Funding/Support: This study was supported by National Cancer Institute grants R25 CA 092203 (Dr Grover) and K07 CA151769 (Dr Kastrinos) and by National Institutes of Health grant K24113433 (Dr Syngal).
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Independent Statistical Analysis: Data sets were forwarded by investigators at Myriad Genetics Laboratories Inc to independent investigators at the Dana-Farber Cancer Institute, Boston, Massachusetts (Drs Grover and Syngal) and the Herbert Irving Comprehensive Cancer Center, New York, New York (Dr Kastrinos). Drs Grover, Kastrinos, and Steyerberg (Center for Medical Decision Making, Erasmus Medical Center, Rotterdam, the Netherlands) performed independent statistical analyses. All results reported in the article are from the independent statistical analyses. None of the coauthors not employed by Myriad Genetics Laboratories Inc received any funding for the study from Myriad Genetics Laboratories Inc.
Disclaimer: No grant support was obtained from Myriad Genetics Laboratories Inc to support the study.