0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Lab Reports |

Airborne Transmission of H5N1

Tracy Hampton, PhD
JAMA. 2012;308(5):444. doi:10.1001/jama.2012.9461.
Text Size: A A A
Published online

Extract

An international team of researchers has identified a combination of 5 mutations that allows for airborne transmission of H5N1 avian influenza virus between ferrets (Herfst S et al. Science. 2012;336[6088]:1534-1541).

Researchers infected ferrets with H5N1 strains containing mutations that would be expected to increase the virus' affinity for mammalian hosts. They then swabbed the animals' noses and inoculated more ferrets, repeating the process several times. Novel mutations appeared, ultimately allowing the virus to become transmissible through the air, as the researchers found when they placed healthy and infected ferrets in adjacent cages but not in direct contact. Four mutations in the gene for hemagglutinin, a protein that helps the virus enter host cells, and 1 in a protein that helps the virus replicate its genome, were consistently present in airborne-transmitted viruses.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();