Author Contributions: Dr Thompson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Thompson, Aberg, Hoy, Telenti, Benson, Cahn, Eron, Günthard, Hammer, Reiss, Richman, Rizzardini, Thomas, Jacobsen, Volberding.
Acquisition of data: Thompson, Hoy, Telenti, Benson, Richman, Volberding.
Analysis and interpretation of data: Thompson, Aberg, Hoy, Benson, Cahn, Eron, Günthard, Hammer, Reiss, Richman, Volberding.
Drafting of the manuscript: Thompson, Aberg, Hoy, Telenti, Benson, Cahn, Richman, Thomas, Jacobsen, Volberding.
Critical revision of the manuscript for important intellectual content: Thompson, Aberg, Hoy, Telenti, Benson, Cahn, Eron, Günthard, Hammer, Reiss, Richman, Rizzardini, Thomas, Volberding.
Obtained funding: Jacobsen.
Administrative, technical, or material support: Jacobsen.
Study supervision: Benson, Jacobsen, Volberding.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest). Disclosure information represents the previous 3 years (updated June 14, 2012). Dr Thompson's institution, AIDS Research Consortium of Atlanta, has received research grants from Boehringer-Ingelheim (BI), Cepheid, GeoVax, Gilead, GlaxoSmithKline (GSK), Kaketsuken, Kowa Research Institute, Merck Research Laboratories, Myriad, Panacos (now Myriad), Peregrine, Pfizer, Pharmasset (now Gilead), Progenics, Roche Molecular Systems, Theratechnologies, Tibotec, Tobira, and Viiv Healthcare. She has served as a clinical trial design consultant for Kowa Research Institute and GeoVax. She also has served on data and safety monitoring boards for GSK/ViiV Healthcare and Tibotec. She participated in 1 scientific advisory consultation on PrEP for Gilead. Her spouse is a former employee of Inhibitex. Dr Aberg has been a scientific advisor to Merck, Tibotec, and ViiV Healthcare. She will receive clinical research support awarded to New York University School of Medicine from Kowa Research Institute in 2012. Dr Hoy has served on the advisory boards for Gilead, ViiV Healthcare, Janssen Cilag, and Merck, Sharp & Dohme (MSD). Her institution has received research support from MSD and Gilead and honoraria for speaking or chairing engagements from Gilead and Janssen Cilag. Her spouse has been a medical advisor/consultant for Roche, MSD, Gilead, Bristol-Myers Squibb (BMS), and Janssen Cilag. He has been a paid speaker and has received conference sponsorship from MSD and BMS. Dr Telenti's institution has received honoraria from his serving on data and safety monitoring boards for GSK and consulting for Merck. His institution has received research funds from Gilead. Dr Benson's spouse has served as a consultant to 3-V Biologicals, Gilead, Inhibitex, Johnson & Johnson Services, Laboratory Corp of America, Merck, Santaris Pharma, and Tobira. He has stock options for Achillion. Dr Cahn has served on advisory boards for Avexa, Gilead, GSK, Merck, Pfizer, and Tibotec. He has served an investigator for Abbott, Avexa, BI, Gilead, GSK, Merck, Pfizer, Pharmasset, Roche, and Tibotec and his institution has received honoraria for speaking or chairing engagements from Abbott, BMS, GSK, Merck, Pfizer, and Tibotec. Dr Eron has received research grants to University of North Carolina from BMS, GSK/Viiv Healthcare, Merck, TaiMed Biologics, and Tobira. He has served as an ad hoc consultant to Avexa, Argos, BMS, Chimerix, Gilead, GSK/Viiv Healthcare, Inhibitex, Merck, Myriad, Pfizer, Tibotec, Tobira, and Virco Laboratories. He is a data and safety monitoring board member for Vertex. Dr Gunthard has served as a medical adviser and/or consultant for Abbott, BI, BMS, Gilead, GSK, Janssen-Cilag, Pfizer, Tibotec, and ViiV Healthcare. He has received unrestricted research and educational grants to his institution from Abbott, BMS, Gilead, GSK, Janssen-Cilag, MSD, Pfizer, and Tibotec. Dr Hammer has served as a scientific advisor to Merck, Progenics, and MedImmune and as a member of data monitoring committees for BMS-sponsored clinical trials. Dr Reiss has served as a scientific advisor to BMS, Gilead, Grupo Ferrer, GSK, Janssen, Merck, and Viiv Healthcare. He has served on data and safety monitoring boards and end-point adjudication committees for Janssen and his institution has received honoraria for speaking engagements at scientific conferences from BMS, Gilead, and GSK. He has received research support from Gilead, ViiV Healthcare, Merck, Janssen, BMS, Abbott, and BI. Dr Richman has been a consultant to Biota, BMS, Chimerix, Gen-Probe, Gilead, Johnson & Johnson, Merck, Monogram Biosciences, and Tobira. He has been the recipient of research grants or contracts from Merck. He has been a stock options holder of Chemerix. Dr Rizzardini has served as a consultant to BMS and on advisory boards of Janssen-Cilag and Gilead Science. His institition has received research support from Gilead, ViiV Healthcare, and Merck. Dr Thomas has received grants and research support from Gilead and Merck and served as a consultant to Merck. Dr Volberding has served on scientific advisory boards for BMS and data and safety monitoring boards for Gilead. No other disclosures were reported.
Funding/Support: This work is supported and funded by the IAS-USA, a mission-based, nonmembership, 501(c)(3) not-for-profit organization. The IAS-USA appointed panel members to develop the guidelines and provide staff support. In the last 5 years, IAS-USA has received commercial support (grants) for selected continuing medical education (CME) activities that are pooled (ie, no single company supports any single effort) from Abbott, BI, BMS, Gilead Sciences, GSK, Janssen, Merck, Pfizer, Roche, Tibotec, Vertex, and ViiV Healthcare. The designation of selected CME activities refers to the IAS-USA structure of only accepting commercial support if there are enough companies with competing products to meet the criteria for independence and only on types of programs that are appropriate for support by commercial sources (eg, guidelines are not supported by industry grants). The IAS-USA also receives support from the Health Resources and Services Administration (HRSA) and the National Resource Center of the AIDS Education and Treatment Centers (via funding from HRSA). No private sector or government funding was used to support the effort. Panel members are not compensated for participation in the effort.
Role of the Sponsor: The IAS-USA determined the need for updated recommendations, selected the panel members based on expertise in research and care to broadly represent developed-world settings affected by HIV disease, and provided administrative oversight and financial support. The panel itself is responsible for the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We thank Michelle Tayag Valderama, BS, IAS-USA, for administrative support. Ms Valderama was compensated as part of her employment.