Author Contributions: Dr Paton had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Paton, Goodall, Dunn, Gazzard, Kelleher.
Acquisition of data: Paton, Goodall, Dunn, Franzen, Collaco-Moraes, Gazzard, Williams, Fisher, Winston, Fox, Orkin, Herieka, Ainsworth, Post, Wansbrough-Jones, Kelleher.
Analysis and interpretation of data: Paton, Goodall, Dunn, Franzen, Collaco-Moraes, Gazzard, Williams, Fisher, Winston, Fox, Orkin, Herieka, Ainsworth, Post, Wansbrough-Jones, Kelleher.
Drafting of the manuscript: Paton, Goodall, Dunn, Collaco-Moraes, Kelleher.
Critical revision of the manuscript for important intellectual content: Paton, Goodall, Dunn, Franzen, Collaco-Moraes, Gazzard, Williams, Fisher, Winston, Fox, Orkin, Herieka, Ainsworth, Post, Wansbrough-Jones, Kelleher.
Statistical analysis: Paton, Goodall, Dunn.
Obtained funding: Paton, Dunn, Gazzard, Kelleher.
Administrative, technical, or material support: Paton, Franzen, Collaco-Moraes, Kelleher.
Study supervision: Paton, Dunn, Gazzard, Kelleher.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: The trial was funded by The Wellcome Trust and supported by the National Institute for Health Research, through the UK Clinical Research Network.
Role of the Sponsor: The funding agency had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
The Hydroxychloroquine Trial Team: Investigators and Site Personnel: Barts and The London (Chloe Orkin, MRCP; James Hand; Carl De Souza, RN, MSc); Brighton and Sussex University Hospital (Martin Fisher, FRCP; Tara Maher; Lisa Heald); Chelsea and Westminster Hospital (Brian Gazzard, MD, FRCP; Katrina Dennis; Jessica Taylor); St Georges Hospital (Mark Wansbrough-Jones, FRCP; Beverly Edwards, BSc); St Mary's Hospital Paddington (Alan Winston, MD, MRCP; Peita-Lee Ambrose; Scott Mullaney, BSN, MSc); UCL-Mortimer Market Centre (Ian Williams, MA, FRCP; Steve O’Farrell); King's College Hospital (Frank Post, MBBS, PhD; Lucy Campbell, BSc, MSc; Emily Wandolo, MSc); North Middlesex University Hospital (Jonathan Ainsworth, FRCP; Anele Waters, BSc); Royal Bournemouth Hospital (Elbushra Herieka, MRCOG; Henry Wilding); St Thomas' Hospital (Julie Fox, MD, FRCP; Isabelle Jendrulek, BA, MA). Central Immunology Laboratory: Peter Kelleher, PhD, MRCPath; Melanie Hart, PhD; Louise Greathead, MChem, MSc; Rebecca Metcalf, PhD; Samuel Franzen, BSc. MRC Clinical Trials Unit: Alejandro Arenas-Pinto, MBBS, PhD; Brian Angus, MD, FRCP; Abdel Babiker, PhD; Ruth Goodall, PhD; David Dunn, PhD; Yolanda Collaco-Moraes, PhD; Kay Taylor; Debbie Johnson, BSc; Patrick Kelleher; Suzie Hennings, BSc, MSc; Fleur Hudson, BA; Filippo Pacciarini, PhD; Liz Brodnicki; Nicholas Paton, MD, FRCP. Trial Steering Committee: Andrew Freedman (Chair), MD, FRCP; David Chadwick, PhD, FRCP; Toju Cline-Cole, BSc, MA; Brian Gazzard, MD, FRCP; Abdel Babiker, PhD; Nicholas Paton, MD, FRCP. Data Monitoring Committee: Tim Peto, BM, DPhil, FRCP; David Lalloo, MD, FRCP.
Additional Contributions: We thank Gary Brooke, MD, FRCP, Central Middlesex Hospital, London, United Kingdom; Mark Gompels, MBBS, BSc, MD, Southmead Hospital, Bristol, United Kingdom; and Brian Angus, MD, FRCP, John Radcliffe Hospital, Oxford, United Kingdom, who assisted with identifying and screening patients for the trial. They were not compensated for their contributions besides salary. We are grateful to all the participants who enrolled in the trial. We also thank the investigators and staff at the participating sites.