The introduction of antiretroviral therapy (ART) for HIV infection in the mid 1990s has transformed a lethal disease into a chronic disease. But despite the success of ART in controlling infection, ART has not been able to eliminate all traces of virus from the body. If treatment is discontinued, viral loads rebound, and treatment also can fail even in the most adherent patients.
Investigators are trying to target quiescent reservoirs of HIV in individuals who are infected with the virus, particularly latent virus in long-lived resting memory CD4 T cells.
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