Author Contributions: Dr Fonarow had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Fonarow, Saver, Reeves, Kleindorfer, Schwamm.
Acquisition of data: Fonarow, Saver, Peterson.
Analysis and interpretation of data: Fonarow, Pan, Saver, Smith, Reeves, Broderick, Kleindorfer, Sacco, Olson, Hernandez, Peterson, Schwamm.
Drafting of the manuscript: Fonarow.
Critical revision of the manuscript for important intellectual content: Fonarow, Pan, Saver, Smith, Reeves, Broderick, Kleindorfer, Sacco, Olson, Hernandez, Peterson, Schwamm.
Statistical analysis: Pan, Saver, Peterson.
Obtained funding: Fonarow.
Administrative, technical, or material support: Fonarow, Saver, Kleindorfer, Olson, Hernandez, Schwamm.
Study supervision: Fonarow, Olson, Schwamm.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Fonarow reported serving as a member of the Get With The Guidelines (GWTG) Steering Committee and receiving research support from the National Institutes of Health and is an employee of the University of California, which holds a patent on retriever devices for stroke. Dr Pan is a member of the Duke Clinical Research Institute (DCRI), which serves as the American Heart Association (AHA) GWTG data coordinating center. Dr Saver reported serving as a member of the GWTG Science Subcommittee and as a scientific consultant regarding trial design and conduct to Covidien, CoAxia, Talacris, Brainsgate, Sygnis, and Ev3 and is an employee of the University of California, which holds a patent on retriever devices for stroke. Dr Smith reported having served on an advisory board to Genentech and is on the data safety and monitoring board for the MR Witness trial. Dr Reeves reported receiving salary support from the Michigan Stroke Registry and serving as a member of the AHA GWTG Quality Improvement Subcommittee. Dr Broderick reported receiving funding from the National Institute of Neurological Disorders and Stroke (NINDS) for multiple ongoing trials; receiving study medications from Genentech for 2 ongoing NINDS studies and having received payment as a consultant to Genentech; and having been reimbursed for travel to meetings by Genentech. Dr Sacco is immediate past president of the AHA. Dr Olson is a member of the DCRI, which serves as the AHA GWTG data coordinating center, and reported serving as a consultant to Bristol Myers Squibb/Sanofi. Dr Hernandez is a member of the DCRI, which serves as the AHA GWTG data coordinating center, and reported being a recipient of an AHA Pharmaceutical Roundtable grant and having received research support from Johnson & Johnson and Amylin. Dr Peterson reported serving as principal investigator of the Data Analytic Center for AHA GWTG; reported receiving research grants from Johnson & Johnson, Eli Lilly, and Janssen Pharmaceuticals; and reported serving as a consultant to Boehringer Ingelheim, Johnson & Johnson, Medscape, Merck, Novartis, Ortho-McNeil-Janssen, Pfizer, Westat, the Cardiovascular Research Foundation, WebMD, and United Healthcare. Dr Schwamm reported serving as chair of the AHA GWTG Steering Committee and as a consultant to the Massachusetts Department of Public Health. No other disclosures were reported.
Funding/Support: The GWTG-Stroke program is provided by the AHA/American Stroke Association. The GWTG-Stroke program is currently supported in part by a charitable contribution from Janssen Pharmaceutical Companies of Johnson & Johnson. GWTG-Stroke has been funded in the past through support from Boehringer-Ingelheim, Merck, Bristol-Myers Squib/Sanofi Pharmaceutical Partnership, and the AHA Pharmaceutical Roundtable.
Role of the Sponsor: The industry sponsors of GWTG-Stroke had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: Dr Peterson, Contributing Editor for JAMA, was not involved in the editorial review of or the decision to publish this article.