To the Editor: Dr Etminan and colleagues1 conducted a case-control analysis of the association of oral fluoroquinolone use with retinal detachment. Understanding the mechanism by which fluoroquinolones may increase retinal detachment risk is important, especially if topical fluoroquinolones, the most common class used during the perioperative period of cataract surgery2 and for contact lens–related infections,3 carry a similar risk.
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