We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Lipid Parameters and Cardiovascular Events in Patients Taking Statins

Seth S. Martin, MD; Steven R. Jones, MD
JAMA. 2012;308(2):131-133. doi:10.1001/jama.2012.6614.
Text Size: A A A
Published online


To the Editor: The meta-analysis by Dr Boekholdt and colleagues1 assessed the associations of multiple lipid parameters with cardiovascular events in patients receiving statins. Levels of low-density lipoprotein cholesterol (LDL-C), non–high-density lipoprotein cholesterol (non–HDL-C), and apolipoprotein B (apoB) were each associated with risk for major cardiovascular events and the strength of association was greatest for non–HDL-C. Levels of LDL-C (the current primary therapeutic goal in the National Cholesterol Education Program guidelines2,3) did not add to risk prediction after accounting for non–HDL-C goal attainment. For example, the authors reported that patients treated with statins who attained the goal of a non–HDL-C level of less than 130 mg/dL, but not the related goal of a LDL-C level of less than 100 mg/dL, did not have increased risk compared with those attaining both goals (hazard ratio [HR], 1.01 [95% CI, 0.92-1.12]; P = .85). In contrast, patients achieving the LDL-C goal but not the non–HDL-C goal had increased risk (HR, 1.32 [95% CI, 1.17-1.50]; P <.001).


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




July 11, 2012
Robert D. Brook, MD; Melvyn Rubenfire, MD
JAMA. 2012;308(2):131-133. doi:10.1001/jama.2012.6616.
July 11, 2012
S. Matthijs Boekholdt, MD, PhD; John J. P. Kastelein, MD, PhD
JAMA. 2012;308(2):131-133. doi:10.1001/jama.2012.6632.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.