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Use of Epinephrine for Cardiac Arrest Prior to Hospital Arrival—Reply

Akihito Hagihara, DMSc, MPH; Takeru Abe, MA; Takashi Nagata, MD
JAMA. 2012;308(1):29-31. doi:10.1001/jama.2012.5944.
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In Reply: Mr Andersen and colleagues were concerned that patients receiving epinephrine comprised a small fraction of the population. Since 2006, certified emergency lifesaving technicians have been permitted to administer epinephrine. The change in epinephrine administration policy during the study period might have contributed to the small fraction of out-of-hospital cardiac arrest patients receiving epinephrine. After the study, the number of such patients receiving epinephrine increased annually from 8124 in 2008 to 11 208 in 2009 and to 14 282 in 2010. We found no factors that suggested selection bias.


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July 4, 2012
Lars Wiuff Andersen, BS; Amanda Graver, MPH; Michael W. Donnino, MD
JAMA. 2012;308(1):29-31. doi:10.1001/jama.2012.5940.
July 4, 2012
Pierre-Nicolas Carron, MD; Patrick Taffe, PhD; Olivier Hugli, MD, MPH
JAMA. 2012;308(1):29-31. doi:10.1001/jama.2012.5942.
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