The importance of a thorough physical examination should be emphasized. Lesions may be hidden under arm boards or tape, at intravenous line sites, or in anatomic areas not readily seen, including the genitals, mucosa, and scalp. Discovery of more than one lesion, as in this case, suggests dissemination, a distinction that changes management and prognosis. A complete skin examination is thus a vital part of the workup of any patient with neutropenia and fever. Skin lesions of angioinvasive fungal infection are typically violaceous papules or plaques with a tendency toward central necrosis resembling a “bull’s-eye infarct.”2 The differential diagnosis of such lesions includes other infectious or noninfectious processes that lead to vascular compromise and skin necrosis, such as ecthyma gangrenosum due to pseudomonal bacteremia, vasculitis, or vasculopathy.