We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Acute Rhinosinusitis Treatment

Gregory DeMuri, MD; Ellen R. Wald, MD
JAMA. 2012;307(22):2368-2370. doi:10.1001/jama.2012.4391.
Text Size: A A A
Published online


To the Editor: Dr Garbutt and colleagues concluded based on a recent trial that treatment of patients with clinically diagnosed acute rhinosinusitis with amoxicillin for 10 days offered little clinical improvement over placebo.1 We have concerns that the study methods confound the conclusions.

First, the criteria used in diagnosing sinusitis, although promulgated by the Centers for Disease Control and Prevention, may be overly broad. Participants were diagnosed with sinusitis if they had maxillary pain or tenderness in the face or teeth, purulent nasal discharge, and rhinosinusitis symptoms lasting 7 days or more. It has been shown that the mean duration of an uncomplicated upper respiratory tract infection in young children is 6.6 to 8.9 days.2 Including patients who have symptoms for less than 10 days may result in including those who have an uncomplicated viral illness and are thus not likely to respond to antimicrobial agents


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




June 13, 2012
Chiang Sun, MD; Hsin-Te Hsu, MD; Shih-Han Hung, MD, MS
JAMA. 2012;307(22):2368. doi:10.1001/jama.2012.4389.
June 13, 2012
Jane Garbutt, MBChB; Edward Spitznagel, PhD; Jay Piccirillo, MD
JAMA. 2012;307(22):2368-2370. doi:10.1001/jama.2012.4393.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...