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Refractory Anemia and Thrombocytopenia Due to Pregnancy

David N. Danforth, M.D.; Franklin A. Kyser, M.D.; Richard C. Boronow, M.D.
JAMA. 1962;180(7):629-631. doi:10.1001/jama.1962.03050200113022a.
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IN OCTOBER, 1960, an example of severe refractory anemia of pregnancy was reported. The condition responded only to blood transfusions; delivery was by cesarian section; and it was concluded that regardless of the severity, this diagnosis does not warrant therapeutic abortion except when proper facilities for observation and management are not available. Blood levels returned to normal after delivery and remained there without further support.

One year after delivery the same patient again became pregnant with a hydatid mole. There was prompt, and more marked, recurrence of anemia and extreme thrombocytopenia. Our efforts to deal with this were to no avail, and the mole was removed by hysterectomy. After operation the blood levels promptly returned to normal, and have so remained since this time. This case is reported as a dramatic clinical problem, and as an additional example of a rare, but most important complication of pregnancy. Also, the extreme


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