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Effect of Pressor Amines on Myocardial Blood Flow in Dogs-Reply

Harold K. Dunn, B.A.
JAMA. 1962;180(5):429. doi:10.1001/jama.1962.03050180074022.
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To the Editor:—  Evaluation of the effect of metaraminol on myocardial blood flow at mean aortic blood pressures greater than 90 mm. Hg was not possible under the conditions of this experiment. When dogs were bled sufficiently to reduce their mean aortic blood pressure to 40 mm. Hg, metaraminol would not raise the mean pressure above 90 mm. Hg regardless of the amount of drug given. Yet if metaraminol was stopped and any of the other pressor amines given in usual doses, the blood pressure could easily be brought up to the 140 mm. Hg range.Due to the length restrictions imposed on papers presented in the Multidiscipline Forum, it was not possible for us to present all our data or a complete discussion of the method used. Therefore it was elected to present the data in as brief and easily comprehensible form as was possible. Within the year we


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