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Slow-Release Trihexyphenidyl in Parkinson's Disease

Robert S. Schwab, M.D.; Lewis J. Doshay, M.D.
JAMA. 1962;180(2):159-161. doi:10.1001/jama.1962.03050150000018a.
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TBIHEXYPHENIDYL (Ariane) hydrochloride was introduced as a synthetic drug for the treatment of Parkinson's disease by Drs. Doshay and Constable in August, 1949. It has proved to be one of the more useful drugs in the treatment of Parkinson's disease, and has been available in 2 mg. and 5 mg. scored tablets for the past 12 years. In addition, an elixir containing 2 mg. of trihexyphenidyl in 4 cc. of liquid has been generally available. Side effects from the drug have been largely benign, disappearing when the drug is reduced or discontinued. It is very similar to any of the belladonna alkaloids in producing dryness of the mouth, and blurred vision. In elderly individuals, if the dosage is pushed too high the side effects are urinary difficulty and sometimes retention, confusion, agitation, and hallucinations, particularly during the night. Trihexyphenidyl, like other atropine drugs, also aggravates a tendency toward constipation and


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