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UNITED KINGDOM

JAMA. 1963;183(9):804. doi:10.1001/jama.1963.03700090124024.
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ABSTRACT

Possible Carcinogenicity of Plastic Sponges.  —According to G. Dukes and B. C. V. Mitchley (Brit Med J, p 1595 [Dec 15] 1962), plastics such as polyvinyl sponges have been used for a bizarre purpose, namely, to construct shapely breasts in cases of hypomastia by the insertion of carefully molded implants of Ivalon polyvinyl sponge between the mammary gland and the underlying pectoral muscle. A disadvantage of the method is that after some months the new "breasts" tend to shrink, and may have to be removed because they become hard and uncomfortable. Dukes and Mitchley have examined eight implants removed from four patients from 4 to 18 mo after insertion and compared the histological changes with those produced experimentally by the subcutaneous implantation of pieces of Ivalon sponge in rats.The changes in the implants removed from both patients and rats were remarkably similar, the interstices of the sponge being filled

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