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MURMURS, SUDDEN DEATH, AND FAMILIAL HEART DISEASE

JAMA. 1963;183(9):785-786. doi:10.1001/jama.1963.03700090105018.
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A favorite choice for presentation at clinical pathological conferences is the case of sudden death or terminal congestive heart failure attributed to myocardial hypertrophy of unknown cause. The adjective "idiopathic" affixed to this syndrome merely places a label upon ignorance. Although recent reports have not provided an answer regarding etiologic factors, they have established a readily identifiable clinical state. This disease usually occurs in the second and third decades and is often characterized by dyspnea, syncopal attacks, and electrocardiographic abnormalities which appear early in the illness. There is roentgenographic evidence of generalized cardiac enlargement, and apical murmurs or those at the left sternal border are common. Autopsies have revealed myocardial hypertrophy and fibrosis with normal values.

Paré and associates1 studied 77 persons in a family in which 50% of the children of any affected member had heart disease. Recognizing that cardiac hypertrophy has been reported to show a familial

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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