Authors/VISION Writing Group:P. J. Devereaux, MD, PhD, Matthew T. V. Chan, MD, Pablo Alonso-Coello, MD, Michael Walsh, MD, MSc, Otavio Berwanger, MD, Juan Carlos Villar, MD, PhD, C. Y. Wang, MBChB, R. Ignacio Garutti, MD, PhD, Michael J. Jacka, MD, MSc, Alben Sigamani, MD, Sadeesh Srinathan, MD, MSc, Bruce M. Biccard, MBChB, PhD, Clara K. Chow, MBBS, PhD, Valsa Abraham, MD, Maria Tiboni, MD, Shirley Pettit, RN, Wojciech Szczeklik, MD, PhD, Giovanna Lurati Buse, MD, Fernando Botto, MD, Gordon Guyatt, MD, MSc, Diane Heels-Ansdell, MSc, Daniel I. Sessler, MD, Kristian Thorlund, PhD, Amit X. Garg, MD, Marko Mrkobrada, MD, Sabu Thomas, MD, Reitze N. Rodseth, MBChB, MMed, Rupert M. Pearse, MBBS, Lehana Thabane, PhD, Matthew J. McQueen, MBChB, PhD, Tomas VanHelder, MD, Mohit Bhandari, MD, MSc, Jackie Bosch, MScAndrea Kurz, MD, Carisi Polanczyk, MD, German Malaga, MD, MSc, Peter Nagele, MD, MSc, Yannick Le Manach, MD, PhD, Martin Leuwer, MD, PhD, Salim Yusuf, MD, DPhil
The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators
Author Contributions: Dr Devereaux had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Chan, Walsh, Villar, Jacka, Botto, Guyatt, Thorlund, Mrkobrada, Thomas, Bhandari, Yusuf, Devereaux.
Acquisition of data: Chan, Alonso-Coello, Walsh, Villar, Wang, Garutti, Sigamani, Srinathan, Biccard, Chow, Abraham, Tiboni, Pettit, Szczeklik, Lurati-Buse, Botto, Mrkobrada, Thomas, Rodseth, Pearse, McQueen, VanHelder, Bosch, Polanczyk, Malaga, Nagele, Yusuf, Devereaux.
Analysis and interpretation of data: Chan, Alonso-Coello, Walsh, Berwanger, Villar, Wang, Szczeklik, Lurati-Buse, Botto, Heels-Ansdell, Sessler, Thorlund, Garg, Mrkobrada, Thomas, Rodseth, Pearse, Thabane, McQueen, VanHelder, Kurz, Polanczyk, LeManach, Leuwer, Yusuf, Devereaux.
Drafting of the manuscript: Devereaux.
Critical revision of the manuscript for important intellectual content: Chan, Alonso-Coello, Walsh, Berwanger, Villar, Wang, Garutti, Jacka, Sigamani, Srinathan, Biccard, Chow, Abraham, Tiboni, Szczeklik, Lurati-Buse, Botto, Guyatt, Heels-Ansdell, Sessler, Thorlund, Garg, Mrkobrada, Thomas, Rodseth, Pearse, Thabane, McQueen, Bhandari, Bosch, Kurz, Polanczyk, Malaga, Nagele, Leuwer, Yusuf, Devereaux.
Statistical analysis: Heels-Ansdell, Thorlund, Thabane.
Obtained funding: Chan, Alonso-Coello, Walsh, Wang, Srinathan, Chow, Thomas, Pearse, Bhandari, Polanczyk, Nagele, Devereaux.
Administrative, technical, or material support: Chan, Walsh, Berwanger, Villar, Sigamani, Srinathan, Biccard, Abraham, Szczeklik, Lurati-Buse, Botto, Mrkobrada, Rodseth, McQueen, Bosch, Leuwer, Yusuf, Devereaux.
Study supervision: Walsh, Garutti, Jacka, Sigamani, Biccard, Tiboni, Szczeklik, Botto, Sessler, McQueen, VanHelder, Bhandari, Malaga, Nagele, Devereaux.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Chan, Walsh, Carlos Villar, Garutti, Jacka, Srinathan, Biccard, Tiboni, Szczeklik, McQueen, VanHelder, Bhandari, Kurz, Malaga, Nagele, Leuwer, and Devereaux; and Ms Bosch report receipt of a grant(s) to their institution from Roche Diagnostics Global Office (Troponin T assays and some financial support for the VISION Study). Dr Chan reports receipt of institutional grants from the Public Policy Research Fund, Research Grant Council, Hong Kong SAR, and a project grant from the Australian and New Zealand College of Anesthesiologists; Drs Alonzo-Coello and Garutti report receipt of institutional grants from Instituto de Salud Carlos III, and Fundació La Marató de TV3; Dr Walsh reports receipt of institutional grants from the Canadian Institutes of Health Research, and Pfizer Canada; Dr Garutti reports receipt of an institutional grant from the Spanish Health Ministry; Dr Srinathan reports receipt of institutional grants from Manitoba Medical Services Foundation, Manitoba Health Research Council, Univerity of Manitoba Department of Surgery, Health Sciences Research Foundation, and employment with the Winnipeg Regional Health Authority; Dr Chow reports receipt of an institutional grant from Abbott, fees for development of educational presentations from AstraZeneca, and that her salary is partially supported by the National Health and Medical Research Council Program Grant (Australia); Dr Abraham reports receipt of an institutional grant from Christian Medical College, Ludhiana; Dr Szczeklik reports having served on the speakers bureau for Jagiellonian University; Drs Guyatt and Devereaux report receipt of an institutional grant from McMaster University (no department specified); Dr Pearse reports receipt of institutional grants from National Institute for Health Research (UK), Circassia Holdings plc, and LiDCo Ltd; consultancy fees from Covidien Inc; and having served on speakers bureaus for Pulsion Medical Systems, Edwards Lifesciences, and B. Braun. Dr McQueen reports receipt of an institutional grant from the Canadian Institutes of Health Research, Sanofi, GlaxoSmithKline, AstraZeneca, Roche, and Beckman; and having served on speakers bureaus for Merck, Roche, and Merck-Frosst. Dr Bhandari reports receipt of institutional grants from Smith & Nephew and DePuy; and provision of consultancy services to Stryker, Smith & Nephew, and Amgen. Dr Malaga reports employment with Universidad Peruana Cayetano Heredia; and Dr Nagele reports receipt of an institutional grant from the American Heart Association, and provision of consultancy services to the Gerson-Lehrman Group. The remainining authors report no disclosures.
Funding/Support: Funding for this study comes from more than 50 grants for VISION and its substudies. Dr Devereaux reports receipt of institutional grants for VISION from: Canadian Institutes of Health Research (6 grants), Heart and Stroke Foundation of Ontario (2 grants), Academic Health Science Centres Alternative Funding Plan Innovation Fund Grant, Population Health Research Institute Grant, Clarity Research Group Grant, McMaster University, Department of Surgery, Surgical Associates Research Grant, Hamilton Health Science New Investigator Fund Grant, Hamilton Health Sciences Grant, Ontario Ministry of Resource and Innovation Grant, Stryker Canada, McMaster University, Department of Anesthesiology (2 grants), Saint Joseph's Healthcare—Department of Medicine (2 grants), Father Sean O’Sullivan Research Centre (2 grants), McMaster University—Department of Medicine (2 grants), Hamilton Health Sciences Summer Studentships (6 grants), McMaster University—Department of Clinical Epidemiology and Biostatistics Grant, McMaster University—Division of Cardiology Grant, and Canadian Network and Centre for Trials International Grant. Other grants provided but not indicated as received by a specific author/institution: Winnipeg Health Sciences Foundation Operating Grant; Diagnostic Services of Manitoba Research Grant; University of Manitoba, Faculty of Dentistry Operational Fund; Projeto Hospitais de Excelência a Serviço do SUS grant from the Brazilian Ministry of Health in Partnership with Hcor (Cardiac Hospital Sao Paulo-SP); School of Nursing, Universidad Industrial de Santander; Grupo de Cardiología Preventiva, Universidad Autónoma de Bucaramanga; Fundación Cardioinfantil—Instituto de Cardiología; Alianza Diagnóstica SA; University of Malaya Research Grant; and University of Malaya, Penyelidikan Jangka Pendek Grant.
Role of the Sponsors: The VISION Study funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript
Operations Committee: P. J. Devereaux, D. I. Sessler, M. Walsh, G. Guyatt, M. McQueen, M. Bhandari, D. Cook, J. Bosch, N. Buckley, P. Raina, and S. Yusuf.
VISION Investigators: Sydney,Australia: Clara K. Chow, Graham S. Hillis, Richard Halliwell, Stephen Li, Vincent W. Lee, and John Mooney. Brazil: Carisi A. Polanczyk and Mariana V. Furtado (Porto Alegre); and Otavio Berwanger, Erica Suzumura, Eliana Santucci, Katia Leite, Jose Amalth do Espirirto Santo, Cesar A. P. Jardim, Alexandre Biasi Cavalcanti, and Helio Penna Guimaraes (Sao Paulo). Canada: Michael J. Jacka, Michelle Graham, Finlay McAlister, Sean McMurtry, Derek Townsend, Neesh Pannu, and Sean Bagshaw, University of Alberta Hospital (Edmonton, Alberta); Mohit Bhandari, John Eikelboom, Javier Ganame, James Hankinson, Stephen Hill, Sanjit Jolly, Andre Lamy, Elizabeth Ling, Patrick Magloire, Karen Raymer, David Szalay, Jacques Tittley, Jeff Weitz, and Richard Whitlock, Hamilton General Hospital, Hamilton Health Sciences (HHS); Saeed Darvish-Kazim, Justin DeBeer, Peter Kavsak, Clive Kearon, Richard Mizera, Martin O’Donnell, Jehonathan Pinthus, Sebastian Ribas, Jagmeet Sethi, Tej Sheth, Marko Simunovic, Tomas VanHelder, and Mitchell Winemaker, Juravinski Hospital and Cancer Centre, HHS; Hertzel Gerstein, Michael Marcaccio, Sarah McDonald, Paul O’Bryne, Ameen Patel, James Paul, Zubin Punthakee, Omid Salehian, Fred Spencer, Stephen Walter, and Andrew Worster, McMaster University Medical Centre, HHS; Anthony Adili, Catherine Clase, Deborah Cook, Mark Crowther, James Douketis, Hugh Fuller, Azim Gangji, Paul Jackson, Wendy Lim, Peter Lovrics, Sergio Mazzadi, William Orovan, Jill Rudkowski, Mark Soth, and Maria Tiboni, St Joseph's Hospital (Hamilton, Ontario); and Sadeesh K. Srinathan, Clare Ramsey, Philip St John, Laurel Thorlacius, Faisal S. Siddiqui, Hilary P. Grocott, Andrew McKay, Justin Wong, Trevor W. R. Lee, Ryan Amadeo, Duane Funk, Heather McDonald, and James Zacharias, Health Sciences Centre Winnipeg (Winnipeg, Manitoba). Bucaramanga, Colombia: Juan Carlos Villar, Olga Lucía Cortés, Maria Stella Chaparro, Skarlett Vásquez, Silvia Fererira, and Alvaro Castañeda. Hong Kong, People's Republic of China: Matthew T. V. Chan, Gordon Y. S. Choi, Tony Gin, and Lydia C. W. Lit. India: Denis Xavier, Alben Sigamani, Atiya Faruqui, Radhika Dhanpal, Smitha Almeida, Joseph Cherian, and Sultana Furruqh (Bangalore); and Valsa Abraham, Lalita Afzal, Preetha George, and Shaveta Mala (Ludhiana). Kuala Lumpur,Malaysia: C. Y. Wang, G. S. Y. Ong, M Mansor, Alvin S. B. Tan, I. I. Shariffuddin, V. Vajiravelu, N. H. M. Hashim, A. Wahab Undok, K. I. Ushananthini, H. Y. Lai, W. A. Wan Azman, and A. H. A. Razack. Lima, Peru: German Malaga, Vanessa Valderrama-Victoria, Daniel Romero-Tuesta, Johanna Vasquez-Grande, and Javier D. Loza-Herrera. Krakow, Poland: Wojciech Szczeklik, Barbara Sokolowska, Jacek Musial, Jacek Gorka, Pawel Iwaszczuk, Krzysztof Zajac, Maciej Chwala, Marcin Zaczek, and Tomasz Mrowiecki. Durban, South Africa: Bruce Biccard, Hussein Cassimjee, Dean Gopalan, Theroshnie Kisten, Aine Mugabi, Prebashini Naidoo, Lucelle Padayachee, Santosh Pershad, Reitze Rodseth, David Skinner, and Alex Torborg. Spain: Pilar Paniagua, Gerard Urrutia, Mari Luz Maestre, Miquel Santaló, Raúl Gonzalez, Adrià Font, Sonia Mirabet, Cecilia Martínez, Xavier Pelaez, Marta De Antonio, Jose Marcial Villamor, Maria José Ferré, Ekaterina Popova, and Pablo Alonso-Coello (Barcelona); and Ignacio Garutti, Patricia Cruz, Carmen Fernández, Susana Díaz, Teresa del Castillo, Angeles de Miguel, Manuel Muñoz, Maria Palencia, Patricia Piñeiro, Alberto Varela, Maria del Barrio, Gabriel Cusati, Alejandro Fernández, Maria José Membrillo, and Hector Bueno (Madrid). England: C. Williams, A. Rushton, I. Welters, and M. Leuwer (Liverpool); and Rupert Pearse, Ahsun Khan, Edyta Niebrzegowska, Sally Benton, Andrew Wragg, Andrew Archbold, Amanda Smith, Eleanor Mcalees, Cheryl Ramballi, Neil Macdonald, and Marta Januszewska (London). United States: Daniel I. Sessler, and Andrea Kurz (Cleveland, Ohio); and Peter Nagele, Jane Blood, Megan Kalin, David Gibson, and Troy Wildes (St Louis, Missouri).
Study Coordination: This study was coordinated by the Clinical Advances Through Research and Information Translation (CLARITY) project office and the Population Health Research Institute (PHRI), at the Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.