Author Contributions: Dr Nicolucci had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: De Berardis, Tognoni, Nicolucci.
Acquisition of data: D’Ettorre, Lepore.
Analysis and interpretation of data: De Berardis, Lucisano, Pellegrini, Lepore, Tognoni, Nicolucci.
Drafting of the manuscript: De Berardis, Lucisano, D’Ettorre, Nicolucci.
Critical revision of the manuscript for important intellectual content: Pellegrini, Lepore, Tognoni.
Statistical analysis: De Berardis, Lucisano, Pellegrini, Nicolucci.
Administrative, technical, or material support: D’Ettorre.
Study supervision: Lepore, Tognoni.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Mr D’Ettorre reported receiving consulting fees from Bristol-Myers Squibb. Dr Tognoni reported receiving a research grant from Bayer. Dr Nicolucci reported receiving a research grant and fees for lectures including service on speakers bureaus from Bayer. Ms De Berardis, Messrs Lucisano and Pellegrini, and Dr Lepore did not report any financial disclosures.
Additional Contributions: We thank the Regional Health Agency and the Department of Health of the Puglia Region for the cooperation, general interest, and provision of data.