0
Letters |

Vitamin D Therapy and Cardiac Function in Chronic Kidney Disease—Reply

Ravi Thadhani, MD, MPH; Hector Tamez, MD, MPH; Scott D. Solomon, MD
JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4176.
Text Size: A A A
Published online

Extract

In Reply: Dr Fourtounas and Drs Rajagopalan and Chan highlight the challenge of identifying the most accurate population for a clinical trial. The PRIMO study aimed to evaluate the effect of activated vitamin D analogs in patients otherwise receiving standard of care therapy in 11 different countries worldwide. Therefore, patients who were well treated according to standard clinical practices, which included use of RAAS inhibitors and other blood pressure agents, were enrolled. While these agents themselves may influence left ventricular hypertrophy,1,2 the conduct of a clinical trial performed on a background of less than standard-of-care therapy would have been unethical, and a positive result from such a trial would have been difficult to interpret. Although paricalcitol did not have an effect on LVMI in patients receiving state-of-the-art care, there was a suggested benefit in other parameters, including cardiovascular hospitalizations, levels of brain natriuretic peptide, and left atrial volume index.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

June 6, 2012
Costas Fourtounas, MD, PhD
JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4168.
June 6, 2012
Sanjay Rajagopalan, MD; Christopher T. Chan, MD
JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4170.
June 6, 2012
Eduardo Slatopolsky, MD
JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4172.
June 6, 2012
Stefan D. Anker, MD, PhD; Stephan von Haehling, MD, PhD
JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4178.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();