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Tropical Medicine

JAMA. 1964;190(11):37-38. doi:10.1001/jama.1964.03070240077042.
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An investigator at the Communicable Disease Center in Atlanta has standardized and evaluated a skin test and serologic procedures for the diagnosis of Echinococcus granulosus in man.

Irving G. Kagan, PhD, chief of the Parasitology Unit, J. J. Osimani, MD, and J. Varela presented their findings at the annual meeting in November of the American Society of Tropical Medicine and Hygiene.

Kagan stated that the diagnosis of hydatid disease by serologic and intradermal tests has been studied for years, but results have been equivocal. Investigators were neither able to quantitate antigens, standardize techniques, nor define parameters of a positive test. By adapting certain techniques of the bilharzia skin test for use in the Casoni skin test, Kagan has been able to achieve definition and standardization.

"Exactly 0.01 ml of antigen was injected intradermally and the area of the wheal, which developed in 15 minutes, was measured. The antigen employed was


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