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Editorials |

DIPYRONE—CHANGE OF STATUS AND LABELING

JAMA. 1964;190(11):1004-1005. doi:10.1001/jama.1964.03070240050015.
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Dipyrone, despite some confusion which may arise from use of various chemical descriptive terms, is simply the sodium sulfonate of aminopyrine. That it is so closely related to the parent compound was not clear in the labeling, which listed it variously as related to aminopyrine or derived from aminopyrine, or which ignored the relationship entirely. Moreover, a tendency to ignore or play down its potential for inducing serious blood dyscrasias was noted in much of the literature. The Council on Drugs attempted to focus attention on dipyrone by means of a communication in the Sept 21 issue of The Journal.1 In this contribution Dr. Huguley reviewed the history of the relationship of aminopyrine to agranulocytosis and emphasized that the relationship was a clear-cut causal one. He also quoted studies in man showing a similar etiological role for dipyrone. He then pointed to the increased use of dipyrone since 1959,

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